Among the deaths is a 15-year-old girl, COVID Commander Jeroen Weimar confirmed.
He noted she had a number of conditions, but was COVID positive.
The results come from more than 79,000 tests conducted, on top of 40,000 vaccines given out.
Mr Weimar said the state has seen a “significant jump” in hospitalisations in the last 24 hours.
“It really reflects the increase in cases we have seen in the last 10 days, 14 days or so,” he said.
“We have 163 people in ICU, and 160 of those are on a ventilator.
“Of those people in hospital yesterday, 89.2 per cent were not fully vaccinated, and of those in ICU yesterday, 95.9 per cent were not fully vaccinated”.
Mr Weimar said there’s a significant growth in COVID-19 cases in Melbourne’s south east, with the City of Casey clocking 1863 active cases.
“In fact Casey, where we are here today, has the most number of cases today of new cases,” he said.
“We are seeing this pattern across the wider south-east. If I look at locations like Hampton Park, Clyde, and Narre Warren, we are seeing significant growth in cases across those communities.
“Similarly across Dandenong, Noble Park and Keysborough, and we are also seeing significant growth in Frankston and out towards Cardinia.”
Mr Weimar said household transmission is fuelling the spread of the virus.
“What we have to be aware of is that all those day-to-day behaviours that we all want to do, but which are not things that we can afford to do are all enabling the virus to spread,” he said.
“Well over two-thirds of the cases we saw yesterday are among people not vaccinated at all.”
Mr Weimar urged Victorians to continue to get vaccinated, announcing pop-up vaccination clinics will be introduced to 11 suburbs across Melbourne.
Currently in Victoria, 87.6 per cent of residents have rolled up their sleeves once. A total of 63.8 per cent are fully vaccinated.
Yesterday, there were 2179 COVID-19 cases recorded and six deaths.
There were almost 700 people in hospital with COVID-19 as of yesterday, including 157 in intensive care and 101 on a ventilator.